Author

M. Hitzenberger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. Zacharias· 4 shared A. Schuetz· 1 shared D. Frishman· 1 shared E. Sakata· 1 shared J. P. L. Coelho· 1 shared K. Leitl· 1 shared K. Meighen-Berger· 1 shared M. J. Feige· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBiophysics

M. Zacharias

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unravelling ATP processing by the AAA+ protein p97 at the atomic level

M. Shein, M. Hitzenberger, T. Cheng, S. Rout, K. Leitl, Y. Sato, M. Zacharias, E. Sakata, A. Schuetz

This study uses cryo-EM, NMR, and MD simulations to reveal the atomic-level mechanism of ATP processing by p97, identifying a metastable ADP.Pi state and its role in coordinating subunit actions.

bioRxiv · Aug 26, 2023Biophysics

Intra-membrane client recognition potentiates the chaperone functions of Calnexin

N. Bloemeke, K. Meighen-Berger, M. Hitzenberger, N. C. Bach, M. Parr, J. P. L. Coelho, D. Frishman, M. Zacharias, S. Sieber, M. J. Feige

This study shows that Calnexin uses its transmembrane domain to recognize and bind misfolded membrane proteins, enhancing its chaperone functions in the ER.

bioRxiv · Mar 7, 2022 · PreprintCell Biology

Uncovering the Binding Mode of γ-Secretase Inhibitors

M. Hitzenberger, M. Zacharias

The paper generates a structural model of γ-secretase bound to a transition state inhibitor, showing good agreement with experimental data and explaining the reduced affinity of an epimer.

bioRxiv · May 13, 2019Biophysics

Structural Modeling of Gamma-Secretase Aβn ComplexFormation and Substrate Processing

M. Hitzenberger, M. Zacharias

The paper generates structural models of GSEC-APP substrate binding and processing using MD simulations, identifying a likely binding mode and analyzing processing steps.

bioRxiv · Dec 20, 2018Biophysics