Author

N. Churgulia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. Cui· 2 shared J. T. Stivers· 2 shared M. Meshesha· 2 shared A. Esadze· 1 shared C. Merlo· 1 shared E. Fuchs· 1 shared J. Breakey· 1 shared S. K. Sahu· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersMicrobiology

J. Cui

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2 papers

Recent·Most cited

Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

J. Cui, M. Meshesha, N. Churgulia, C. Merlo, E. Fuchs, J. Breakey, J. T. Stivers

This study shows that replication-competent HIV persists in alveolar macrophages and monocytes despite high dUTP levels and low UNG activity, suggesting dUMP incorporation does not fully block viral replication in vivo.

bioRxiv · May 3, 2022Microbiology

Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages

M. Meshesha, A. Esadze, J. Cui, N. Churgulia, S. K. Sahu, J. T. Stivers

This study shows that monocytes lack functional uracil base excision repair, leading to persistent dUMP in HIV proviruses, while macrophages have limited hUNG2 activity, affecting viral infectivity and diversification.

PLOS ONE · Jul 14, 2020Peer-reviewedMicrobiology