Author

J. T. Stivers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. Bosbach· 2 shared B. Orris· 2 shared D. J. Shields· 2 shared J. Cui· 2 shared K. W. Huynh· 2 shared M. Meshesha· 2 shared N. Churgulia· 2 shared S. Han· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

B. Bosbach

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

B. Orris, M. W. Sung, S. Bhat, Y. Xu, K. W. Huynh, S. Han, D. C. Johnson, B. Bosbach, D. J. Shields, J. T. Stivers

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

bioRxiv · Jun 15, 2023 · PreprintBiochemistry

Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

J. Cui, M. Meshesha, N. Churgulia, C. Merlo, E. Fuchs, J. Breakey, J. T. Stivers

This study shows that replication-competent HIV persists in alveolar macrophages and monocytes despite high dUTP levels and low UNG activity, suggesting dUMP incorporation does not fully block viral replication in vivo.

bioRxiv · May 3, 2022Microbiology

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation, and ssDNA binding kinetics

B. Orris, K. W. Huynh, M. Ammirati, S. Han, B. Bolanos, J. Carmody, M. D. Petroski, B. Bosbach, D. J. Shields, J. T. Stivers

This study shows that phosphorylation of SAMHD1 at Thr592 increases tetramer dynamics and ssDNA binding, leading to rapid inactivation of dNTPase activity at stalled replication forks.

bioRxiv · Apr 5, 2022Biochemistry

Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages

M. Meshesha, A. Esadze, J. Cui, N. Churgulia, S. K. Sahu, J. T. Stivers

This study shows that monocytes lack functional uracil base excision repair, leading to persistent dUMP in HIV proviruses, while macrophages have limited hUNG2 activity, affecting viral infectivity and diversification.

PLOS ONE · Jul 14, 2020Peer-reviewedMicrobiology