A feedback-loop between telomerase activity and stemness factors regulates PDAC stem cells
K. Walter, E. Rodriguez-Aznar, M. S. Ventura-Ferreira, P. O. Frappant, T. Dittrich, K. Tiwary, S. Meessen, L. Lerma, N. Daiss, L. A. Schulte, F. Arnold, N. Azoitei, M. Erkan, A. Lehel, T. Bruemmendorf, , P. C. Hermann
This study shows that telomerase activity and stemness factors form a feedback loop that maintains pancreatic cancer stem cells, and disrupting this loop reduces their tumorigenic potential.
bioRxiv · Nov 2, 2020 · PreprintCancer Biology