Structural and Biochemical Studies of Dihydrofolate Reductase from Streptococcus pyogenes as a Target for Antifolate Antibiotics
B. Hajian, J. Krucinska, M. Martins, N. G-Dayanan, K. Viswanathan, S. Tavakoli, D. Wright
This study identifies potent DHFR inhibitors against S. pyogenes and determines its crystal structure to guide antifolate antibiotic development.
bioRxiv · Dec 21, 2018 · PreprintMicrobiology