Author

J. Krucinska

Primary ORCID profile (0000-0002-3787-7194 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

J. KrucinskaiD1 paper · University of Connecticut

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

K. Viswanathan· 2 shared A. A. Ojewole· 1 shared A. Estrada· 1 shared A. J. Weimer· 1 shared B. Hajian· 1 shared B. R. Donald· 1 shared D. L. Wright· 1 shared D. Si· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

K. Viswanathan

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Author profile →

2 papers

Recent·Most cited

Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

S. M. Reeve, D. Si, J. Krucinska, Y. Yan, K. Viswanathan, S. Wang, G. T. Holt, M. S. Frenkel, A. A. Ojewole, A. Estrada, S. S. Agabiti, J. B. Alverson, N. D. Gibson, A. J. Weimer, B. R. Donald, D. L. Wright

The paper develops novel inhibitors targeting DHFR enzymes in MRSA to overcome trimethoprim resistance, showing low nanomolar activity and human selectivity.

bioRxiv · May 24, 2019Biochemistry

Structural and Biochemical Studies of Dihydrofolate Reductase from Streptococcus pyogenes as a Target for Antifolate Antibiotics

B. Hajian, J. Krucinska, M. Martins, N. G-Dayanan, K. Viswanathan, S. Tavakoli, D. Wright

This study identifies potent DHFR inhibitors against S. pyogenes and determines its crystal structure to guide antifolate antibiotic development.

bioRxiv · Dec 21, 2018 · PreprintMicrobiology