Chemoproteomics-guided Development of SLC15A4 Inhibitors with Anti-inflammatory Activity
D. C. Lazar, W. W. Wang, T.-Y. Chiu, W. Li, A. M. Jadhav, J. M. Wozniak, N. Gazaniga, J. Teijaro, C. G. Parker
The paper develops first-in-class SLC15A4 inhibitors that suppress endosomal TLR and NOD signaling in immune cells and show anti-inflammatory effects in vivo and clinical settings.
bioRxiv · Oct 7, 2022Immunology