Combi-Seq: Multiplexed transcriptome-based profiling of drug combinations using 1deterministic barcoding in single-cell droplets
Lukas Mathur, Bence Szalai, N. H. Du, Ramesh Utharala, Martine Ballinger, Jonathan J. M. Landry, Michaël Ryckelynck, Vladimı́r Beneš, Julio Sáez-Rodríguez, Christoph A. Merten
The paper develops a method to screen drug combinations using single-cell transcriptome analysis, identifying synergistic and antagonistic pairs in K562 cells.
Nature Communications · Aug 1, 2022Peer-reviewedSystems Biology