A Universal Allosteric Mechanism for G Protein Activation
K. M. Knight, S. Ghosh, S. L. Campbell, T. J. Lefevre, R. H. J. Olsen, A. V. Smrcka, N. H. Valentin, G. Yin, N. Vaidehi, H. G. Dohlman
This paper identifies a conserved Gly-Arg-Glu motif that mediates G protein subunit dissociation through an allosteric mechanism, and shows that mutations in this motif cause human diseases.
bioRxiv · Nov 15, 2020Biochemistry