Author

S. L. Campbell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. V. Smrcka· 1 shared B. E. Schaffer· 1 shared C. M. Furdui· 1 shared C. Mesaros· 1 shared D. Parsonage· 1 shared G. A. Hobbs· 1 shared G. Yin· 1 shared H. Affronti· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

A. V. Smrcka

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Author profile →

3 papers

Recent·Most cited

Kinetic and Redox Characterization of KRAS G12C Inhibition

M. V. Huynh, D. Parsonage, T. E. Forshaw, V. R. Chirasani, G. A. Hobbs, H. Wu, J. Lee, C. M. Furdui, L. B. Poole, S. L. Campbell

This study characterizes the kinetic and redox properties of KRASG12C inhibition, revealing pH-dependent covalent ligation and oxidation effects on protein conformation.

bioRxiv · Apr 3, 2022Biochemistry

A Universal Allosteric Mechanism for G Protein Activation

K. M. Knight, S. Ghosh, S. L. Campbell, T. J. Lefevre, R. H. J. Olsen, A. V. Smrcka, N. H. Valentin, G. Yin, N. Vaidehi, H. G. Dohlman

This paper identifies a conserved Gly-Arg-Glu motif that mediates G protein subunit dissociation through an allosteric mechanism, and shows that mutations in this motif cause human diseases.

bioRxiv · Nov 15, 2020Biochemistry

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

S. L. Campbell, C. Mesaros, L. Izzo, H. Affronti, T. Tsang, M. Noji, B. E. Schaffer, K. Sun, S. Trefely, S. Kruijning, J. Blenis, I. A. Blair, K. E. Wellen

This study shows that glutamine deprivation in pancreatic ductal adenocarcinoma cells increases free GlcNAc and activates NAGK-dependent hexosamine salvage to support tumor growth.

bioRxiv · Sep 13, 2020Cancer Biology