Rifampicin and rifabutin resistance in 1000 Mycobacterium tuberculosis clinical isolates
M. R. Farhat, J. Sixsmith, R. Calderon, N. Hicks, S. Fortune, M. Murray
The paper investigates rifamycin resistance in Mycobacterium tuberculosis isolates, finding that the D435V rpoB mutation increases IC50 for both rifampicin and rifabutin, suggesting the need to revise RFB testing concentrations.
bioRxiv · Sep 25, 2018Evolutionary Biology