S. Fortune

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

The paper shows that CD4 T cells and innate CD8+ lymphocytes are essential for IV BCG-induced protection against tuberculosis in macaques.

Global analysis of the specificities and targets of endoribonucleases from E. coli toxin-antitoxin systems

The paper characterizes the targets and specificities of 9 endoribonuclease toxins from E. coli using a new RNA-seq pipeline, revealing they cleave mRNAs but not tRNAs or rRNAs and disrupt ribosome biogenesis.

Spontaneous control of SIV replication does not prevent immune dysregulation and bacterial dissemination in animals co-infected with M. tuberculosis

This study shows that SIV+ animals, regardless of viral control, have higher Mtb burden and dysregulated immune responses, leading to increased bacterial dissemination.

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

Fluorescence Imaging-Based Discovery of Membrane Domain-Associated Proteins in Mycobacterium smegmatis

The paper uses fluorescence imaging to verify and discover new proteins associated with the intracellular membrane domain in Mycobacterium smegmatis.

Rifampicin and rifabutin resistance in 1000 Mycobacterium tuberculosis clinical isolates

The paper investigates rifamycin resistance in Mycobacterium tuberculosis isolates, finding that the D435V rpoB mutation increases IC50 for both rifampicin and rifabutin, suggesting the need to revise RFB testing concentrations.

Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response

The paper uses dual RNAseq to analyze leprosy lesions, linking bacterial states to host immune responses through type I IFNs and antibody pathways.

Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages

This study compares CD4+ and CD8+ T cell recognition of Mtb-infected macrophages, finding CD8+ T cells poorly recognize infected macrophages despite strong immunodominant responses.