Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission
R. S. Lach, C. Qiu, E. Z. Kajbaf, N. J. Baxter, D. Han, A. Y. Wang, H. M. Lock, O. Chirikin, B. L. Pruitt, M. Z. Wilson
The paper shows that centrosome-nucleated biomolecular condensates of the Destruction Complex enhance β-catenin degradation and regulate Wnt signaling in human embryonic stem cells.
bioRxiv · Feb 1, 2022Cell Biology