Teratogenic Drug Topiramate Upregulates TGFβ1 and SOX9 Expression in Primary Palatal Mesenchyme Cells
S. K. Rafi, J. P. Goering, A. J. Olm-Shipman, L. A. Hipp, N. J. Ernst, N. R. Wilson, E. G. Hall, S. Gunewardena, I. Saadi
This study shows topiramate increases TGFβ1 and SOX9 in palatal mesenchyme cells, potentially causing orofacial clefts through GABA receptor activation.
bioRxiv · Dec 31, 2019Pharmacology & Toxicology