Polymerization of misfolded protein lowers CX3CR1 expression in human PBMCs
S. Tumpara, M. Ballmaier, S. Wrenger, M. König, M. Lehmann, R. Lichtinghagen, B. Martinez-Delgado, D. DeLuca, N. Jedicke, T. Welte, M. Fromme, P. Strnad, J. Stolk, S. Janciauskiene
This study shows that polymerized misfolded Z-AAT protein reduces CX3CR1 expression on human PBMCs, suggesting a role for extracellular misfolded proteins in immune regulation.
bioRxiv · Nov 24, 2020Cell Biology