Editing of the Human TRIM5 Gene to Introduce Mutations with the Potential to Inhibit HIV-1
C. Dufour, A. Claudel, N. Joubarne, N. Merindol, T. Maisonnet, M. B. Plourde, L. Berthoux
This study edits the human TRIM5 gene to introduce HIV-1 inhibitory mutations but finds limited restriction activity in HEK293T cells.
bioRxiv · Oct 3, 2017Microbiology