M. B. Plourde

Editing of the TRIM5 gene decreases the permissiveness of human T lymphocytic cells to HIV-1

This study edits the TRIM5 gene in human T cells to restrict HIV-1 infection, showing biallelic modification is needed for significant inhibition.

Editing of the Human TRIM5 Gene to Introduce Mutations with the Potential to Inhibit HIV-1

This study edits the human TRIM5 gene to introduce HIV-1 inhibitory mutations but finds limited restriction activity in HEK293T cells.

Gene knockout shows that PML (TRIM19) does not restrict the early stages of HIV-1 infection in human cell lines

This paper uses CRISPR-Cas9 to knockout PML in human cell lines and shows it does not restrict early HIV-1 infection or IFN-I-mediated inhibition.