Nanomolar, noncovalent antagonism of hedgehog cholesterolysis: exception to the irreversibility rule for protein autoprocessing inhibition.
A. G. Wagner, R. T. Stagnitta, Z. Xu, J. Pezzullo, N. Kandel, D. F. Covey, J.-L. Giner, C. Wang, B. P. Callahan
The paper identifies noncovalent, reversible inhibitors of HhC cholesterolysis, challenging the irreversibility rule for protein autoprocessing inhibition.
bioRxiv · Sep 1, 2021Biochemistry