The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages
Y. Duan, J. Wang, J. Cai, N. Kelley, Y. He
This study shows that the LRR domain of NLRP3 is essential for its inflammasome activation in macrophages by enabling self-association, oligomerization, and interaction with NEK7.
bioRxiv · May 25, 2022Immunology