Author

N. Kurt-Yilmaz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:structural biology· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. A. Schiffer· 2 shared F. Leidner· 2 shared A. Ali· 1 shared J. Timm· 1 shared K. KosovrastiiD· 1 shared M. HenesiD· 1 shared S. Hou· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

C. A. Schiffer

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2 papers

Recent·Most cited

Deciphering complex mechanisms of resistance and loss of potency through coupled molecular dynamics and machine learning.

F. Leidner, N. Kurt-Yilmaz, C. A. Schiffer

This paper uses molecular dynamics and machine learning to identify conserved dynamic mechanisms of drug resistance in HIV-1 protease variants.

Journal of Chemical Theory and Computation · Apr 13, 2021Peer-reviewedBiophysics

Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir

J. Timm, K. Kosovrasti, M. Henes, F. Leidner, S. Hou, A. Ali, N. Kurt-Yilmaz, C. A. Schiffer

This study determines the crystal structures of HCV NS3/4A protease from multiple genotypes bound to glecaprevir, revealing molecular mechanisms of pan-genotypic inhibition and resistance-associated substitutions.

ACS Chemical Biology · Dec 23, 2019Peer-reviewedBiochemistry