Author

J. Timm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 4 Assay:structural biology· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Ali· 2 shared C. A. Schiffer· 2 shared E. Arnold· 2 shared F. X. Ruiz· 2 shared K. KosovrastiiD· 2 shared M. HenesiD· 2 shared P. R. Griffin· 2 shared R. Yadav· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

A. Ali

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

R. Yadav, V. V. Courouble, S. K. Dey, J. J. E. K. Harrison, J. Timm, J. B. Hopkins, R. L. Slack, S. G. Sarafianos, F. X. Ruiz, P. R. Griffin, E. Arnold

The paper elucidates the structural basis and cleavage order of SARS-CoV-2 nsp7-11 polyprotein processing by Mpro, with implications for Mpro inhibition.

bioRxiv · May 27, 2022Biochemistry

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

J. Zephyr, D. N. Rao, S. V. Vo, M. Henes, K. Kosovrasti, A. N. Matthew, A. K. Hedger, J. Timm, E. T. Chan, A. Ali, N. K. Yilmaz, C. A. Schiffer

The paper investigates how fluorination of HCV protease inhibitors improves resistance to the D168A variant by enabling alternate binding conformations through co-crystal structure analysis.

Journal of Molecular Biology · May 1, 2022Peer-reviewedBiochemistry

Design of a Minimal di-Nickel Hydrogenase Peptide

J. A. Mancini, D. H. Pike, S. Poudel, J. Timm, A. M. Tyryshkin, J. Siess, P. Molinaro, J. J. McCann, K. M. Waldie, R. L. Koder, P. G. Falkowski, V. Nanda

The paper designs a minimal di-nickel hydrogenase peptide capable of producing molecular hydrogen from protons under various conditions, suggesting early enzymes evolved from simple peptides.

bioRxiv · Apr 9, 2022 · PreprintBiochemistry

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics

V. Courouble, S. Dey, R. Yadav, J. Timm, J. Harrison, F. X. Ruiz, E. Arnold, P. R. Griffin

This study uses HDX-MS and XL-MS to analyze the structural dynamics of the full-length SARS-CoV-2 nsp7:nsp8 complex, revealing conformational flexibility and a different assembly model compared to SARS-CoV.

bioRxiv · Mar 6, 2021 · PreprintBiophysics

SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects

J. Gopalakrishnan, A. Ramani, L. Mueller, P. Niklas Ostermann, E. Gabriel, A. Islam Pranty, A. Mueller-Shiffmann, A. Mariappan, O. Goureau, H. Gruell, A. Walker, M. Andree, S. Hauka, K. Wohlgemuth, H. Omran, , A. Dilthey

This study shows SARS-CoV-2 infects cortical neurons in 3D human brain organoids, causing neurodegeneration-like effects such as Tau mislocalization and neuronal death.

bioRxiv · May 20, 2020Cell Biology

Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir

J. Timm, K. Kosovrasti, M. Henes, F. Leidner, S. Hou, A. Ali, N. Kurt-Yilmaz, C. A. Schiffer

This study determines the crystal structures of HCV NS3/4A protease from multiple genotypes bound to glecaprevir, revealing molecular mechanisms of pan-genotypic inhibition and resistance-associated substitutions.

ACS Chemical Biology · Dec 23, 2019Peer-reviewedBiochemistry