The analysis of the role of MexAB-OprM on quorum sensing homeostasis shows that the apparent redundancy of Pseudomonas aeruginosa multidrug efflux pumps allows keeping the robustness and the plasticity of this intercellular signaling network
M. Alcalde-Rico, J. Olivares-Pacheco, N. M. Halliday, M. Camara, J. L. Martinez
This study shows that overexpression of MexAB-OprM in Pseudomonas aeruginosa impairs quorum sensing by reducing intracellular octanoate, not by extruding the QS signal, highlighting the distinct mechanisms of efflux pump redundancy.
bioRxiv · Mar 10, 2020 · PreprintMicrobiology