Author

M. Alcalde-Rico

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Organism:bacteria (other)· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. L. Martinez· 3 shared A. Quesille-Villalobos· 2 shared B. Hanson· 2 shared C. A. Arias· 2 shared J. M. Munita· 2 shared J. Olivares-Pacheco· 2 shared J. R. Martinez· 2 shared J. Reyes· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMicrobiology

J. L. Martinez

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5 papers

Recent·Most cited

Efflux pump mutations in Pseudomonas aeruginosa cause low-level clinical resistance and high-level tolerance to antibiotics in patients

P. Laborda, S. Lolle, S. Hernando-Amado, M. Alcalde-Rico, J. L. Martinez, S. Molin, H. K. Johansen

This study shows that mexZ mutations in Pseudomonas aeruginosa lead to antibiotic tolerance and altered colonization in human airway models through overexpression of lecA.

bioRxiv · Aug 18, 2023 · PreprintMicrobiology

Heavy Metal Pollution From a Major Earthquake and Tsunami in Chile Is Associated With Geographic Divergence of Clinical Isolates of Methicillin-Resistant Staphylococcus aureus in Latin America

J. R. Martinez, M. Alcalde-Rico, E. Jara-Videla, R. Rios, A. M. Moustafa, B. Hanson, L. Rivas, L. P. Carvajal, S. Rincon, L. Diaz, J. Reyes, A. Quesille-Villalobos, R. Riquelme-Neira, E. A. Undurraga, J. Olivares-Pacheco, , J. M. Munita

This study links heavy-metal pollution from a Chilean earthquake and tsunami to the geographic spread of MRSA clones in Latin America.

bioRxiv · May 18, 2023 · PreprintMicrobiology

Dynamics of the MRSA Population in A Chilean Hospital: A Phylogenomic Analysis (2000-2016)

J. R. Martinez, P. J. Planet, M. Spencer-Sandino, L. Rivas, L. Diaz, A. Quesille-Villalobos, R. Riquelme-Neira, M. Alcalde-Rico, B. Hanson, L. P. Carvajal, S. Rincon, J. Reyes, M. Lam, R. Araos, P. Garcia, , J. M. Munita

This study analyzes MRSA clonal dynamics in a Chilean hospital from 2000-2016, finding increased diversity and the emergence of new clones replacing the dominant ChC clone.

bioRxiv · Feb 6, 2023Microbiology

The analysis of the role of MexAB-OprM on quorum sensing homeostasis shows that the apparent redundancy of Pseudomonas aeruginosa multidrug efflux pumps allows keeping the robustness and the plasticity of this intercellular signaling network

M. Alcalde-Rico, J. Olivares-Pacheco, N. M. Halliday, M. Camara, J. L. Martinez

This study shows that overexpression of MexAB-OprM in Pseudomonas aeruginosa impairs quorum sensing by reducing intracellular octanoate, not by extruding the QS signal, highlighting the distinct mechanisms of efflux pump redundancy.

bioRxiv · Mar 10, 2020 · PreprintMicrobiology

Novel inducers of the expression of multidrug efflux pumps that trigger Pseudomonas aeruginosa transient antibiotic resistance

P. Laborda, M. Alcalde-Rico, P. Blanco, J. L. Martinez, S. Hernando-Amado

This study identifies non-antibiotic compounds that induce multidrug efflux pumps in Pseudomonas aeruginosa, leading to transient antibiotic resistance.

bioRxiv · May 30, 2019Microbiology