The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death
H. Jiang, S. Panda, X. Xue, F. Liang, P. Sung, N. O. Gekara
This study identifies cGAS as a negative regulator of homologous recombination DNA repair, leading to genome instability and cell death.
bioRxiv · Nov 8, 2018Cell Biology