Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43-toxicity
M. Koopman, L. Gungordu, L. Janssen, R. I. Seinstra, J. E. X. Richmond, N. Okerlund, R. Wardenaar, P. Islam, A. E. X. Brown, E. M. Jorgensen, E. A. A. Nollen
This study identifies that rebalancing excitatory and inhibitory inputs in C. elegans restores movement in a TDP-43 toxicity model by synergizing neurotransmitter system enhancements.
bioRxiv · Oct 24, 2023 · PreprintCell Biology