R. Wardenaar

CDC20 determines the sensitivity to spindle assembly checkpoint (SAC) inhibitors

The paper identifies CDC20 expression as a determinant of sensitivity to SAC inhibitors, showing that aneuploid cells with high CDC20 levels are more sensitive to these drugs.

Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43-toxicity

This study identifies that rebalancing excitatory and inhibitory inputs in C. elegans restores movement in a TDP-43 toxicity model by synergizing neurotransmitter system enhancements.

Tracking genome evolution in single cell clones reveals the rates and features of copy number alterations generated by ongoing chromosomal instability in cancer.

The paper tracks genome evolution in single-cell clones to reveal copy number alteration rates and features in cancer driven by chromosomal instability.

Oncogenic functions of the m6A demethylase FTO in breast cancer cells involving translational upregulation of C/EBPβ-LIP

This study shows FTO promotes oncogenic functions in TNBC by regulating C/EBPβ-LIP translation, which drives EMT and metastasis.

Centrosome amplification primes for apoptosis and favors the response to chemotherapy in ovarian cancer beyond multipolar divisions

The paper shows centrosome amplification in ovarian cancer cells primes them for apoptosis and improves chemotherapy response, independent of multipolar divisions and chromosome instability.

Short-term molecular consequences of chromosome mis-segregation for genome stability

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

A motor-based approach to induce chromosome-specific mis-segregations in human cells

This paper introduces a motor-based method to induce chromosome-specific mis-segregations in human cells, revealing how spindle forces can cause aneuploidies.

Inducing Specific Chromosome Mis-Segregation in Human Cells

This study induces specific chromosome mis-segregation in human cells using CRISPR-Cas9 to create designer karyotypes and study aneuploidy's cellular effects.

Patient-derived parathyroid organoids as tracer and drug-screening application model

This study develops patient-derived parathyroid organoids that mimic parathyroid tissue function and respond to calcium and drugs, showing potential for therapeutic and imaging tracer research.

Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts

This study shows that gut microbiota transplantation from CST-KO mice to wild-type mice induces colonic fibrosis and tight junction impairment, suggesting a causal role for microbiota in intestinal dyshomeostasis linked to catestatin deficiency.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

Genetic instability from a single S-phase after whole genome duplication

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

TP53 loss initiates chromosomal instability in high-grade serous ovarian cancer

This study shows that TP53 loss in fallopian tube epithelial cells drives chromosomal instability through cell cycle deregulation, without requiring additional mutations.

Inhalable textile microplastic fibers impair airway epithelial growth

This study shows nylon microplastic fibers impair airway epithelial growth in organoids, likely due to leaching components, highlighting risks of indoor exposure.

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

This study compares chronic and transient chromosomal instability in mice, showing that transient instability accelerates tumor formation through rapid clonal evolution.

Aneuploidy-driven genome instability triggers resistance to chemotherapy

This study shows that aneuploidy-induced genome instability helps cancer cells resist chemotherapy by enabling survival under drug pressure.