Mycobacterium tuberculosis requires the outer membrane lipid phthiocerol dimycocerosate for starvation-induced antibiotic tolerance
A. M. Block, S. B. Namugenyi, N. P. Palani, A. M. Brokaw, L. Zhang, K. B. Beckman, A. D. Tischler
This paper identifies phthiocerol dimycocerosate (PDIM) as essential for Mycobacterium tuberculosis antibiotic tolerance under nutrient starvation, suggesting PDIM synthesis as a target to enhance antibiotic efficacy.
bioRxiv · Jul 7, 2022Microbiology