Distinct neurotoxic TDP-43 fibril polymorphs can be generated by heterotypic interactions with α-synuclein
S. Dhakal, A. S. Robang, N. Bhatt, N. Pungamalai, L. Fung, R. Kayed, A. K. Paravastu, V. Rangachari
This study shows that α-synuclein can generate distinct TDP-43 fibril polymorphs through heterotypic interactions, leading to synaptic dysfunction.
bioRxiv · Jun 14, 2022 · PreprintBiophysics