S. Dhakal

Estradiol Mediates Greater Germinal Center Responses to Influenza Vaccination in Female than Male Mice

This study shows estradiol enhances germinal center responses and antibody production in female mice after influenza vaccination, leading to better protection against viral challenge.

α-Synuclein emulsifies TDP-43 prion-like domain - RNA liquid droplets to promote heterotypic amyloid fibrils

This study shows α-synuclein emulsifies TDP-43 prion-like domain-RNA droplets, promoting heterotypic amyloid fibril formation.

Extraction and characterization of cellulose from invasive weeds from central Nepal: A potential prospect of environmental management.

This study extracts and characterizes cellulose from invasive weeds in Nepal, showing it can be used as a sustainable alternative to plastics and textiles.

Distinct neurotoxic TDP-43 fibril polymorphs can be generated by heterotypic interactions with α-synuclein

This study shows that α-synuclein can generate distinct TDP-43 fibril polymorphs through heterotypic interactions, leading to synaptic dysfunction.

Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells

This study shows that female mice have stronger and more diverse antibody responses to influenza vaccination, leading to better protection against mutant viruses due to increased germinal center B cell activity.

Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption

This study shows that GM1-enriched liposomes promote toxic Aβ oligomerization and membrane disruption through cooperative processes.

αS oligomers generated from polyunsaturated fatty acid and dopamine metabolite differentially interact with Aβ to enhance neurotoxicity

This study investigates how αS oligomers from DOPAL and DHA interact with Aβ, showing differential effects on Aβ aggregation and toxicity in neuroblastoma cells.

A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant

Progression and Resolution of SARS-1 CoV-2 Infection in Golden Syrian Hamsters

This study tracks SARS-CoV-2 infection progression in golden Syrian hamsters, showing weight loss, lung damage, and resolution over time.

Cytoplasmic Colocalization of Granulins and TDP-43 Prion-like Domain Involves Electrostatically Driven Coacervation Tuned by the Redox State of Cysteines.

This study shows extracellular granulins colocalize with TDP-43 prion-like domain fragments in neuroblastoma cells and undergo phase separation driven by electrostatic interactions and cysteine redox state.

Protective efficacy of an orf virus-vector encoding the hemmagglutinin and the nucleoprotein of influenza A virus in swine

This study evaluates two recombinant orf viruses expressing hemagglutinin (HA) or HA and nucleoprotein (NP) of IAV-S in pigs, finding that OV-HA-NP provides better protection against swine influenza with reduced virus shedding and viral load.

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

Prion-like C-terminal domain of TDP-43 and α-Synuclein interact synergistically to generate neurotoxic hybrid fibrils

This study investigates the synergistic interaction between TDP-43's prion-like domain and α-synuclein, showing they form toxic hybrid fibrils with increased cytotoxicity.

Post-intervention Epidemiology of STH in Bangladesh: data to sustain the gains

The paper evaluates the post-intervention impact of STH control programs in Bangladesh, showing a significant reduction in prevalence across all ages but persistent high transmission in some districts.

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

This study determines cryo-EM structures of KIF14 bound to microtubules with nucleotide analogues, revealing conformational changes linked to ATP hydrolysis and motor function.