Skeletal Muscle mTORC1 Activation Increases Energy Expenditure and Reduces Longevity in Mice
E. J. Stephenson, J. R. Redd, D. Snyder, Q. T. Tran, B. Lu, M. J. Peloquin, M. C. Mulcahy, I. Harvey, K. Fisher, J. C. Han, N. Qi, A. R. Saltiel, D. Bridges
This study shows that activating mTORC1 in skeletal muscle increases energy expenditure but shortens lifespan in mice.
bioRxiv · Jul 31, 2019 · PreprintPhysiology