N. R. Forde

Fluence-dependent degradation of fibrillar type I collagen by 222 nm far-UVC radiation

This study investigates how 222 nm far-UVC radiation affects type I collagen fibrils in vitro, showing fluence-dependent degradation and suggesting safe fluence ranges for internal tissue disinfection.

AutoSmarTrace: Automated Chain Tracing and Flexibility Analysis of Biological Filaments

AutoSmarTrace automates chain tracing and persistence length calculation from single-molecule images, showing agreement with ground truth and previous methods.

Sequence-dependent mechanics of collagen reflect its structural and functional organization

This study uses AFM to analyze how sequence variations in collagen IV and III affect their local flexibility, revealing that helix interruptions significantly influence mechanical properties.

Environmentally controlled curvature of single collagen proteins

This study investigates collagen flexibility using AFM and a new algorithm, finding that collagen's conformation is modulated by salt and pH, not flexibility, and behaves as a curved worm-like chain.

Single-molecule assay for proteolytic susceptibility using centrifuge force microscopy:force-induced destabilization of collagen‘s triple helix

The paper introduces a method to measure force-dependent proteolytic cleavage using a centrifuge force microscope, showing increased trypsin sensitivity under mechanical load.

Genetically modified human type II collagen for N- and C-terminal covalent tagging

This paper describes a method to genetically modify human type II collagen for covalent N- and C-terminal tagging using mutations and enzymatic processing.