The ClpX chaperone controls the Staphylococcus aureus cell cycle but can be bypassed by β-lactam antibiotics
K. T. Baek, C. Jensen, C. Gallay, N. S. Fisker, I. Thalsoe-Madsen, A. R. Pereira, W. Paulander, J.-W. Veening, M. G. Pinho, D. Frees
This paper shows that β-lactam antibiotics can bypass the growth defect of S. aureus clpX mutants by restoring septum synthesis and preventing premature cell lysis.
bioRxiv · May 3, 2018Microbiology