Author

M. G. Pinho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 6 Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2

Frequent Co-Authors

B. M. Saraiva· 3 shared P. Reed· 3 shared A. C. Tavares· 2 shared A. D. Brito· 2 shared A. R. Pereira· 2 shared H. Veiga· 2 shared J. M. Monteiro· 2 shared L. B. Marques· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMicrobiology

B. M. Saraiva

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Author profile →

9 papers

Recent·Most cited

Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus

L.-Y. Lai, N. Satishkumar, S. Cardozo, V. Hemmadi, L. B. Marques, L. Huang, S. R. Filipe, M. G. Pinho, H. F. Chambers, S. S. Chatterjee

This study identifies that mutations in PBP4 and GdpP synergistically confer high-level, broad-spectrum β-lactam resistance in mecA-deficient Staphylococcus aureus strains.

bioRxiv · Oct 26, 2023 · PreprintMicrobiology

Processive movement of Staphylococcus aureus essential septal peptidoglycan synthases is independent of FtsZ treadmilling and drives cell constriction

S. Schaeper, A. D. Brito, B. M. Saraiva, G. R. Squyres, M. J. Holmes, E. C. Garner, Z. Hensel, R. Henriques, M. G. Pinho

This study shows that FtsW/PBP1 and DivIB move processively around the division site in S. aureus, driving cell constriction independently of FtsZ treadmilling.

bioRxiv · Jun 29, 2023Microbiology

The role of GpsB in cell morphogenesis of Staphylococcus aureus

S. F. Costa, B. M. Saraiva, H. Veiga, L. B. Marques, S. Schaper, M. Sporniak, D. E. Vega, A. M. Jorge, A. M. Duarte, A. D. Brito, A. C. Tavares, P. Reed, M. G. Pinho

This study identifies GpsB as a key protein involved in cell elongation in S. aureus by affecting the localization of PBPs and peptidoglycan synthesis.

bioRxiv · Jun 16, 2023 · PreprintMicrobiology

A CRISPRi-based genetic resource to study essential Staphylococcus aureus genes

P. Reed, M. Sorg, D. Alwardt, L. Serra, H. Veiga, S. Schaeper, M. G. Pinho

The paper develops a CRISPRi system for gene knockdown in S. aureus and constructs a library of 261 strains targeting 200 essential genes.

bioRxiv · Oct 31, 2022Microbiology

DeepBacs: Bacterial image analysis using open-source deep learning approaches

C. Spahn, R. F. Laine, P. M. Pereira, E. Gomez-de-Mariscal, L. von Chamier, M. Conduit, M. G. Pinho, S. Holden, G. Jacquemet, M. Heilemann, R. Henriques

DeepBacs uses open-source deep learning to analyze bacterial microscopy images, offering tools for segmentation, classification, and phenotyping with applications in antibiotic research.

bioRxiv · Nov 3, 2021Microbiology

The cell cycle in Staphylococcus aureus is regulated by an amidase that controls peptidoglycan synthesis

T. Do, K. Schaefer, A. G. Santiago, K. A. Coe, P. B. Fernandes, D. Kahne, M. G. Pinho, S. Walker

This study identifies an amidase complex that spatially regulates peptidoglycan synthesis in S. aureus, controlling cell growth and division by modulating synthase activity and movement.

bioRxiv · May 10, 2019Microbiology

SEDS-bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus

N. T. Reichmann, A. C. Tavares, B. M. Saraiva, A. Jousselin, P. Reed, A. R. Pereira, J. M. Monteiro, M. S. VanNieuwenhze, F. Fernandes, M. G. Pinho

This study identifies two SEDS-bPBP pairs in Staphylococcus aureus that mediate lateral and septal peptidoglycan synthesis, maintaining coccoid morphology.

bioRxiv · Feb 17, 2019Microbiology

The pentaglycine bridges of Staphylococcus aureus peptidoglycan are essential for cell integrity

J. M. Monteiro, D. Munch, S. R. Filipe, T. Schneider, H.-G. Sahl, M. G. Pinho

This study shows that pentaglycine crosslinks in Staphylococcus aureus peptidoglycan are essential for cell integrity, as their absence leads to cell lysis and requires high osmolarity for survival.

bioRxiv · Nov 27, 2018Microbiology

The ClpX chaperone controls the Staphylococcus aureus cell cycle but can be bypassed by β-lactam antibiotics

K. T. Baek, C. Jensen, C. Gallay, N. S. Fisker, I. Thalsoe-Madsen, A. R. Pereira, W. Paulander, J.-W. Veening, M. G. Pinho, D. Frees

This paper shows that β-lactam antibiotics can bypass the growth defect of S. aureus clpX mutants by restoring septum synthesis and preventing premature cell lysis.

bioRxiv · May 3, 2018Microbiology