Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer's disease.
N. Salvadores, I. Moreno, N. Gamez, G. Quiroz, L. Vegas, M. Escandon, S. Jimenez, J. Vitorica, A. Gutierrez, C. Soto, F. Court
This study shows Aβ oligomers induce necroptosis in neurons via microglia activation, leading to neurodegeneration in Alzheimer's disease, and suggests necroptosis inhibition as a potential therapeutic target.
bioRxiv · Aug 27, 2021Cell Biology