Promyelocytic Leukemia (PML) Nuclear Bodies (NBs) Induce Latent/Quiescent HSV-1 Genomes Chromatinization Through a PML-NB/Histone H3.3/H3.3 Chaperone Axis
C. Cohen, A. Corpet, M. A. Maroui, O. Binda, N. Poccardi, A. Rousseau, P. Texier, N. Sawtell, M. Labetoulle, P. Lomonte
This study shows PML-NBs facilitate HSV-1 latency by promoting H3.3-dependent chromatinization of viral genomes through H3.3 chaperone complexes.
bioRxiv · Nov 9, 2017Microbiology