C. Cohen

The HUSH epigenetic repressor complex silences PML nuclear bodies-associated HSV-1 quiescent genomes

This paper identifies the HUSH-SETDB1-MORC2 complex as essential for maintaining HSV-1 latency by promoting H3K9me3 chromatin marks on viral genomes in neurons.

Cilia to basement membrane signalling is a biomechanical driver of autosomal dominant polycystic kidney disease

This study identifies biomechanical changes in the tubular basement membrane as drivers of cyst formation in ADPKD, linking cilia and polycystin-1 function.

Rapid Emergence and Evolution of SARS-CoV-2 Variants in Advanced HIV Infection

This study shows that advanced HIV infection leads to high intra-host SARS-CoV-2 spike diversity and adaptive evolution, potentially contributing to new variants of concern.

Kinetics of zoospores approaching a root using a microfluidic device

This study uses a microfluidic device with a growing Arabidopsis root to analyze the kinetics of Phytophthora zoospores approaching and aggregating on the root, finding that behavior changes only near the aggregation site and aggregation rate depends on zoospore density.

Enterobacteriaceae isolated from patients share antibiotic resistance conferring plasmids recently acquired from those isolated from sinks in the same treatment room

The paper identifies shared antibiotic resistance plasmids between patient and sink isolates, suggesting plasmid transmission from sinks to patients.

Coordination of two opposite flagella allows high-speed swimming and active turning of individual zoospores

This study investigates how two opposite flagella in Phytophthora zoospores generate thrust and enable turning, revealing distinct roles for each flagellum in swimming behavior.

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

This study shows that SARS-CoV-2 501Y.V2 pseudovirus escapes neutralization by South African convalescent plasma but not binding, suggesting potential for reinfection and reduced vaccine efficacy.

Loss of genome maintenance accelerates podocyte damage

This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.

Environmental shedding of toxigenic Clostridioides difficile by asymptomatic carriers: A prospective observational study

This study compares environmental shedding of toxigenic C. difficile between asymptomatic carriers, CDI patients, and non-carriers, finding carrier rooms are as contaminated as CDI rooms but more than control rooms.

Guidance of zoospores by potassium gradient sensing mediates aggregation

This study shows that potassium gradients guide zoospore aggregation through a sequence of chemotaxis and bioconvection in Phytophthora parasitica.

Promyelocytic Leukemia (PML) Nuclear Bodies (NBs) Induce Latent/Quiescent HSV-1 Genomes Chromatinization Through a PML-NB/Histone H3.3/H3.3 Chaperone Axis

This study shows PML-NBs facilitate HSV-1 latency by promoting H3.3-dependent chromatinization of viral genomes through H3.3 chaperone complexes.