Pharmacology & ToxicologybioRxiv
A pharmacokinetic-pharmacodynamic assessment of the hepatic and bone-marrow toxicities of the new trypanoside fexinidazole
J. A. Watson, N. Strub-Wourgraft, A. Tarral…·N. J. White
This study assesses the toxicity of fexinidazole in Chagas and g-HAT patients, finding dose-dependent neutropenia, thrombocytopenia, and hepatotoxicity in Chagas but not g-HAT.
DOI 10.1128/aac.02515-18