Low-bias ncRNA Libraries using Ordered Two-Template Relay: Serial Template Jumping by a Modified Retroelement Reverse Transcriptase
h. e. upton, l. ferguson, m. m. Temoche-Diaz, x. liu, s. c. pimentel, n. t. ingolia, r. schekman, K. Collins
This paper develops OTTR, a low-bias RNA sequencing method using retroelement RTs, outperforming commercial kits and enabling comprehensive ncRNA inventories.
bioRxiv · Apr 30, 2021Biochemistry