Author

H. E. Upton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:long-read sequencing· 1 Assay:metagenomics· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

K. Collins· 2 shared S. C. Pimentel· 2 shared A. Shaw· 1 shared C. J. Bustamante· 1 shared H. Amiri· 1 shared J. H. Gundlach· 1 shared J. Kim· 1 shared J. M. Craig· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

K. Collins

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Author profile →

2 papers

Recent·Most cited

Nanopore molecular trajectories of a eukaryotic reverse transcriptase reveal a long-range RNA structure sensing mechanism

A. Shaw, J. M. Craig, H. Amiri, J. Kim, H. E. Upton, S. C. Pimentel, J. R. Huang, S. Marqusee, J. H. Gundlach, K. Collins, C. J. Bustamante

The paper uses nanopore sequencing to study the single-nucleotide kinetics of a reverse transcriptase, revealing its ability to sense and destabilize RNA structures during cDNA synthesis.

bioRxiv · Apr 5, 2023 · PreprintBiophysics

Low-bias ncRNA Libraries using Ordered Two-Template Relay: Serial Template Jumping by a Modified Retroelement Reverse Transcriptase

h. e. upton, l. ferguson, m. m. Temoche-Diaz, x. liu, s. c. pimentel, n. t. ingolia, r. schekman, K. Collins

This paper develops OTTR, a low-bias RNA sequencing method using retroelement RTs, outperforming commercial kits and enabling comprehensive ncRNA inventories.

bioRxiv · Apr 30, 2021Biochemistry