mtDNA replication in dysfunctional mitochondria promotes deleterious heteroplasmy via the UPRmt
Q. Yang, P. Liu, N. Anderson, T. Shpilka, Y. Du, N. Uma Naresh, K. Luk, J. Lavelle, R. Zeinert, P. Chien, S. Wolfe, C. Haynes
The paper shows ATFS-1 promotes {Delta}mtDNA replication by recruiting POLG, while LONP-1 inhibition increases wildtype mtDNA binding and improves heteroplasmy ratio and OXPHOS function.
bioRxiv · Sep 1, 2020 · PreprintCell Biology