Werner helicase control of human papillomavirus 16 E1-E2 DNA replication is regulated by SIRT1 deacetylation
I. M. Morgan, D. Das, M. Bristol, N. W. Smith, X. Wang, P. Pichierri
This paper shows that SIRT1 deacetylates WRN to regulate its interaction with E1-E2 replicating DNA, controlling replication fidelity and quantity in HPV16.
bioRxiv · Oct 23, 2018Microbiology