P. Pichierri

Functional correlation between WRN and SAMHD1 in end-resection

This study shows SAMHD1 influences WRN recruitment to DSBs and their cooperative role in DNA repair, with SAMHD1 compensating for WRN deficiency in some contexts.

Switch-Like Phosphorylation of WRN Integrates End-Resection with RAD51 Metabolism at Collapsed Replication Forks

This study identifies phosphorylation events on WRN that regulate end-resection and RAD51-mediated repair at replication forks.

A double-ring of human RAD52 remodels replication forks restricting fork reversal

The paper shows human RAD52 forms a double-ring structure around stalled replication forks, remodeling them via DNA strand exchange to prevent reversal by SMARCAL1.

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES

This study shows that phosphorylation-dependent WRN-RPA interaction is essential for replication fork recovery after stalling at secondary DNA structures, preventing DNA damage and G4 accumulation.

WRNIP1 prevents transcription-associated genomic instability

This study identifies WRNIP1 as a factor that prevents transcription-associated genomic instability by resolving R-loop conflicts and limiting DNA damage.

RAD52 prevents accumulation of Polα-dependent replication gaps at perturbed replication forks

This study shows RAD52 prevents Polα-dependent replication gaps by enabling RAD51/Pol repriming at reversed replication forks, which limits DNA damage and improves cell viability during replication stress.

WRNIP1 PREVENTS G4/R-LOOP-ASSOCIATED GENOMIC INSTABILITY

This study identifies WRNIP1's role in preventing DNA damage caused by G4/R-loop-associated transcription-replication conflicts by stabilizing FANCJ at G4 sites.

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency

This study identifies CHK2's role in regulating MUS81-dependent DSBs during replication stress and BRCA2 deficiency by phosphorylating MUS81.

Phosphorylation Status Of MUS81 Is A Modifier Of Olaparib Sensitivity In BRCA2-Deficient Cells

This study shows that phosphorylation status of MUS81 affects PARPi sensitivity in BRCA2-deficient cells by modulating MUS81 activity in different phases of the cell cycle.

Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instability

The paper shows WRNIP1 stabilizes genome integrity by mediating ATM-dependent CHK1 phosphorylation and RAD51 ssDNA association in response to R-loop accumulation.

Generation of inducible SMARCAL1 knock-down iPSC to model severe Schimke immune-osseous dysplasia reveals a link between replication stress and altered expression of master differentiation genes

This study generates SMARCAL1 knock-down iPSCs to model Schimke immune-osseous dysplasia, revealing replication stress and altered gene expression as key factors in disease pathogenesis.

Werner helicase control of human papillomavirus 16 E1-E2 DNA replication is regulated by SIRT1 deacetylation

This paper shows that SIRT1 deacetylates WRN to regulate its interaction with E1-E2 replicating DNA, controlling replication fidelity and quantity in HPV16.

RAD51 AND MITOTIC FUNCTION OF MUS81 ARE ESSENTIAL FOR RECOVERY FROM LOW-DOSE OF CAMPTOTHECIN IN THE ABSENCE OF THE WRN EXONUCLEASE

The paper investigates how WRN exonuclease deficiency affects replication fork recovery from camptothecin, showing RAD51 and MUS81 mitotic function are essential to prevent genome instability.

Phosphorylation By CK2 Regulates MUS81/EME1 In Mitosis And After Replication Stress

This study shows CK2 phosphorylates MUS81 at Serine 87 in mitosis and under replication stress, promoting its interaction with SLX4 and affecting chromosome stability.