I. M. Morgan

E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer

This study shows that HPV E7 represses miR-203, leading to LASP1 upregulation and promoting proliferation in HPV-positive cervical cancer.

Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.

The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

This paper shows that MARCHF8 stabilizes HPV E7 by degrading CUL1 and UBE2L3, preventing E7 degradation in HPV+ HNC cells.

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function

This study shows that E2 protein interaction with BRD4's CTM and TopBP1 is essential for HPV16's mitotic chromatin association and plasmid segregation, offering therapeutic targets for viral genome targeting.

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycle.

This paper shows that HPV16 and HPV11 E2 proteins require interaction with TopBP1 for stability, and disrupting this interaction with CK2 inhibitors like CX4945 promotes viral genome integration and could be a therapeutic strategy.

HPV E6 upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer

Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis

This study shows that HPV E6 reduces mitochondrial antioxidant capacity and therapy resistance in oropharyngeal cancer by suppressing the PGC-1α/ERRα pathway.

Human papillomavirus 16 E2 repression of TWIST1 transcription is a potential mediator of HPV16 cancer outcomes

This paper shows that HPV16 E2 represses TWIST1 transcription, which may explain the better clinical outcomes in HPV16 positive cancers.

Estrogen attenuates the growth of human papillomavirus positive epithelial cells

This paper shows estrogen reduces growth of HPV-positive epithelial cells through two mechanisms, suggesting it could be a therapeutic for HPV+HNSCC.

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models

This study identifies predictors of HPV-related head and neck squamous cell carcinoma progression and survival using patient-derived models and finds associations between mutational burden and E2F target dysregulation with clinical outcomes.

SAMHD1 regulates human papillomavirus 16 induced cell proliferation and viral replication during differentiation of oral keratinocytes.

This study shows that HPV16 regulates SAMHD1 expression in oral keratinocytes, and SAMHD1 deletion enhances viral replication and cell proliferation in HPV16-infected cells.

PTPN14 Degradation by High-Risk Human Papillomavirus E7 Limits Keratinocyte Differentiation and Contributes to HPV-Mediated Oncogenesis

This study shows that high-risk HPV E7 degrades PTPN14, impairing keratinocyte differentiation and contributing to oncogenesis independent of RB1 inactivation.

Werner helicase control of human papillomavirus 16 E1-E2 DNA replication is regulated by SIRT1 deacetylation

This paper shows that SIRT1 deacetylates WRN to regulate its interaction with E1-E2 replicating DNA, controlling replication fidelity and quantity in HPV16.