Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response
T. Pauzaite, N. Wit, R. V. Seear, J. A. Nathan
The paper identifies USP43 as a deubiquitinating enzyme that enhances HIF-1 nuclear accumulation and target gene binding through interaction with 14-3-3 proteins under hypoxia.
bioRxiv · Jan 10, 2024 · PreprintCell Biology