J. A. Nathan

Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response

The paper identifies USP43 as a deubiquitinating enzyme that enhances HIF-1 nuclear accumulation and target gene binding through interaction with 14-3-3 proteins under hypoxia.

Glutarate regulates T cell function and metabolism

This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.

LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein

The paper identifies LRRC15 as a novel host factor that interacts with SARS-CoV-2 spike protein, distinct from ACE2 and other known receptors, and shows it modulates viral infection.

Cigarette smoke preferentially induces full length ACE2 exposure in primary human airway cells but does not alter susceptibility to SARS-CoV-2 infection

The paper investigates how cigarette smoke affects ACE2 expression in airway cells and finds it increases full-length ACE2 without increasing SARS-CoV-2 infectivity.

Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated primary human airway cells

This study shows topical camostat mesylate inhibits SARS-CoV-2 infection in human airway cells, suggesting it could be used for pre- or post-exposure prophylaxis.

A thermostable, closed, SARS-CoV-2 spike protein trimer.

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

ABHD11 regulates 2-oxoglutarate abundance by protecting mitochondrial lipoylated proteins from lipid peroxidation damage

The paper identifies ABHD11 as a mitochondrial hydrolase that protects lipoylated proteins from lipid peroxidation, thereby regulating 2-OG levels and 2-OG DD function.

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

This study identifies RNF145 as a sterol-responsive E3 ubiquitin ligase that, along with gp78 and Hrd1, mediates HMGCR degradation in response to sterol levels.