LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition
This paper shows LRRK2 suppresses lysosome activity in macrophages and microglia by inhibiting MiT-TFE transcription factors, linking LRRK2 hyperactivity to increased Parkinson's disease risk.
bioRxiv · Dec 17, 2022Cell Biology