S. M. Ferguson

A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

This study identifies a STING-CASM-GABARAP pathway that activates LRRK2 at lysosomes in response to lysosomal stress and links it to disease relevance in Parkinson's and Crohn's disease.

LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

This paper shows LRRK2 suppresses lysosome activity in macrophages and microglia by inhibiting MiT-TFE transcription factors, linking LRRK2 hyperactivity to increased Parkinson's disease risk.

LyTS: A Lysosome Localized Complex of TMEM192 and STK11IP

The paper identifies TMEM192 and STK11IP as forming a lysosome-localized complex, LyTS, essential for lysosome homeostasis.

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

The paper shows that VPS13C deficiency leads to lysosomal lipid changes and activates the cGAS/STING pathway via mtDNA accumulation and impaired STING degradation.

PQLC2 signals lysosomal cationic amino acid abundance to the C9orf72 complex

The paper identifies PQLC2 as a lysosomal cationic amino acid transporter that interacts with the C9orf72 complex and regulates its recruitment based on amino acid availability.

Weak Membrane Interactions Allow Rheb to Activate mTORC1 Signaling Without Major Lysosome Enrichment

This study shows Rheb activates mTORC1 signaling through weak ER membrane interactions, not lysosome targeting.

Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis

This study investigates the effects of TDP-43 depletion and mutations on cell morphology, mRNA splicing, and disease pathology in human cells.