hENT Inhibition Prevents Pyrimidine-Driven Resistance to DHODH Inhibition in Malignant Rhabdoid Tumors
Marjolein M G Kes, Giulia Perticari, Jolanda Kooiman, Nadia Anderson, Jeroen W. A. Jansen, Esther A. Zaal, Celia R. Berkers, Jarno Drost
This study shows that hENT inhibition overcomes pyrimidine-driven resistance to DHODH inhibition in SWI/SNF-deficient pediatric cancers.
bioRxiv · Jan 27, 2026 · PreprintCancer Biology