Celia R. Berkers

The paper develops an in vitro MASH model to study metabolite crosstalk between Kupffer cells and hepatocytes, identifying itaconate as a key mediator of liver disease progression.

This paper introduces Full Scan enhanced Dynamic Range MS to improve metabolite detection in untargeted metabolomics, increasing feature detection and enabling better discrimination between cancer cell lines.

This study shows that hepatic stellate cells enhance HCC proliferation through HIF-dependent metabolic changes and H2O2 signaling.

This paper uses metabolomics co-variation networks to analyze urobiome-pathogen interactions, identifying keystone species and emergent pathogen states in a synthetic urobiome model.

This study shows that hENT inhibition overcomes pyrimidine-driven resistance to DHODH inhibition in SWI/SNF-deficient pediatric cancers.

This study identifies picornavirus proteins that inhibit de novo nucleotide synthesis during infection using metabolomics and recombinant virus analysis.

This study shows that bacterial Hsp90 enhances protein refolding after heat stress but is not required for de novo folding, revealing its ancient role in the chaperone cascade.