Chromatin protein complexes involved in gene repression in lamina-associated domains
Stefano Giustino Manzo, Abdelghani Mazouzi, Christ Leemans, Tom van Schaik, Nadia Neyazi, Marjon S. van Ruiten, Benjamin D. Rowland, Thijn R. Brummelkamp, Bas van Steensel
The paper identifies chromatin regulators involved in gene repression in lamina-associated domains (LADs) through genetic screens, showing that transcription elongation and chromatin remodeling factors, not nuclear lamina proteins, mediate repression.
The EMBO Journal · Sep 25, 2024Peer-reviewedMolecular Biology